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NO-Brinzolamide

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SI-4008

NO-Brinzolamide, >98% (HPLC)

CAS No. : [1068439-19-9]

IUPAC Name : (R)-3-(4-(Ethylamino)-1,1-dioxido-6-sulfamoyl-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazin-2-yl)propyl nitrate

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Chemical Properites
Mol. Formula :
C11H18N4O7S3
Mol. Weight :
414.48
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : NO-Brinzolamide is a NO-donor containing carbonic anhydrase (CA) inhibitor. This is shown improved efficacy of lowering IOP in both rabbits and monkeys compared to Brinzolamide.

References : Huang Q. et al.: J. Med. Chem., 58(6), 2821-2833, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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