NRL-1049 dihydrochloride

SI-6309

NRL-1049 dihydrochloride, >98% (HPLC)

CAS No. : [1973494-17-5]

Synonyms : BA-1049

IUPAC Name : (R)-1-(1-(Isoquinolin-5-ylsulfonyl)piperidin-4-yl)ethan-1-amine dhydrochloride

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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : NRL‑1049 dihydrochloride selectively inhibits ROCK2 with sub‑micromolar potency and shows markedly reduced activity toward ROCK1. It preserves blood–brain barrier integrity after acute injury, making it a valuable tool for probing ROCK2‑mediated neurovascular stabilization.

References : Mulder I. A. et al.: J. Cereb. Blood Flow Metab., 44(11), 1238-1252, 2024.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.