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NS1738

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SI-5672

NS1738, >98% (HPLC)

CAS No. : [501684-93-1]

MDL No. : MFCD11100189

Synonyms : NSC 213859.

IUPAC Name : 1-(5-Chloro-2-hydroxyphenyl)-3-(2-chloro-5-(trifluoromethyl)phenyl)urea

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Chemical Properites
Mol. Formula :
C14H9Cl2F3N2O2
Mol. Weight :
365.13
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : NS1738 is a novel positive allosteric modulator (PAM) of the α7 nAChR, with respect to positive modulation of α7 nAChR (EC50=3.4 μM in oocyte experiments). NS1738 is developing for the potential treatment of cognitive dysfunction.

References : Timmermann D. B. et al.: J. Pharmacol Exp. Ther., 323(1), 294-307, 2007.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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