NS5A inhibitor

SI-6071

NS5A inhibitor, >98% (HPLC)

IUPAC Name : Dimethyl ((2S,2'S,3R,3'R)-((2S,2'S)-(((((2S,5S)-1-(4-(4,4-dimethyl-1,4-azasilinan-1-yl)-3,5-difluorophenyl)pyrrolidine-2,5-diyl)bis(4,1-phenylene))bis(azanediyl))bis(carbonyl))bis(pyrrolidine-2,1-diyl))bis(3-methoxy-1-oxobutane-1,2-diyl))dicarbamate

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a pangenotypic HCV NS5A inhibitor incorporating a 4‑silapiperidine motif, delivering exceptional potency (EC₅₀ = 0.33–17 pM across GT1–GT6) and improved activity against the GT1a_M28T resistance variant. It shows strong metabolic stability, favorable PK, and high liver distribution in mouse, rat, and dog. A 14‑day repeat‑dose toxicity study supports its safety, positioning it as a high‑quality lead for HCV therapy development.

References : Liu B. et al.: J. Med. Chem., 63(10), 5312-5323, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.