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NTRC-0066-0

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SI-6257

NTRC-0066-0, >98% (HPLC)

CAS No. : [1817791-73-3]

IUPAC Name : N-(2,6-Diethylphenyl)-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide

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Chemical Properites
Mol. Formula :
C33H39N7O2
Mol. Weight :
565.72
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : NTRC-0066‑0 selectively inhibits TTK with sub‑nanomolar potency (IC50 = 0.9 nM), supporting its application in studies of mitotic checkpoint control, chromosomal‑segregation fidelity, and cancer‑cell proliferation.

References : Uitdehaag JCM. et al.: J. Mol. Biol., 429(14), 2211-2230, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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