NU-223612

SI-7207

NU-223612, >98% (HPLC)

CAS No. : [2759420-43-2]

IUPAC Name : (2R)-N-(4-((1-(3-(2-(2-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)propanoyl)piperidin-4-yl)oxy)phenyl)-2-((1s,4S)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : NU-223612 is a potent PROTAC that degrades IDO1 with a Kd of 640 nM through CRBN‑mediated proteasomal degradation. It binds CRBN with an affinity of 290 nM and is capable of crossing the blood–brain barrier.

References : Bollu R. L. et al.: J. Med. Chem., 65(23), 15642-15662, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.