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NVP-TNKS656

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SL-1441

NVP-TNKS656, >98%

CAS No. : [1419949-20-4]

MDL No. : MFCD28167762

Synonyms : TNKS656

IUPAC Name : N-(Cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-4,5,7,8-tetrahydro-3H-pyrano[4,3-d]pyrimidin-2-yl)methyl)acetamide

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Chemical Properites
Mol. Formula :
C27H34N4O5
Mol. Weight :
494.58
Appearance :
White solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM, and is > 300 fold selectivity against PARP1 and PARP2.

References : Shultz M. D. et al.: J. Med. Chem., 56(16), 6495, 2013; Arqués O. et al.: Clin. Cancer Res., 22(3), 644, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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