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O-Desacetyl-N-desmethyl diltiazem

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O-Desacetyl-N-desmethyl diltiazem, >98%

CAS No. : [86408-44-8]

MDL No. : MFCD00871883

Synonyms : Deacetyl N-monodesmethyl diltiazem; Diltiazem EP impurity G

IUPAC Name : (2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-5-(2-(methylamino)ethyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one

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Chemical Properites
Mol. Formula :
C19H22N2O3S
Mol. Weight :
358.45
Appearance :
Pale yellow solid
Melting Point :
Not available
Solubility :
Methanol
For Laboratory research use only, not for drug, household or other uses.

Applications : O-Desacetyl-N-desmethyl diltiazem is a metabolite of Diltiazem, which is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist). Diltiazem EP impurity G.

References : Kraus R. L. et al.: J. Biol Chem., 273(42), 27205-27212, 1998; Freitas F. et al.: Fundam Clin. Pharmacol., 29(1), 31-40, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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