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O-Desmethyl staurosporin

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SL-5944

O-Desmethyl staurosporin, >98%

CAS No. : [161743-35-7]

Synonyms : 3'-Demethyl staurosporine

IUPAC Name : (5R,7R,8R,9S)-8-Hydroxy-9-methyl-7-(methylamino)-6,7,8,9,14,15-hexahydro-5H,16H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-16-one

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Chemical Properites
Mol. Formula :
C27H24N4O3
Mol. Weight :
452.51
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : O-Desmethyl staurosporin is a metabolite of Staurosporine, which is a potent PKC inhibitor, it induces apoptosis in many cell types.

References : Tang D. et al.: J. Biol Chem., 275(13), 9303-9307, 2000; Deng X. et al.: Proc Natl Acad Sci U S A, 97(4), 1578-1583, 2000; Johansson A. C. et al.: Cell Death Differ., 10(11), 1253-1259, 2003; Manns J. et al.: FASEB J. 25(9), 3250-3261, 2011; Hara H. et al.: J. Cereb Blood Flow Metab., 10(5), 646-653, 1990.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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