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Ocifisertib hydrochloride

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SI-8025

Ocifisertib hydrochloride, >98% (HPLC)

CAS No. : [1338799-83-9]

Synonyms : CFI-400945 hydrochloride

IUPAC Name : (1R,2S)-2-(3-((E)-4-(((2S,6R)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one hydrochloride

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25MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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250MGRequest A Quote
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Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C33H34N4O3 • HCl
Mol. Weight :
571.12
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Ocifisertib hydrochloride is an orally active PLK4 inhibitor with high potency (Ki = 0.26 nM; IC50 = 2.8 nM). It blocks cancer‑cell proliferation, triggers G2/M arrest and apoptosis, and exhibits significant antitumor effects in vivo.

References : Sampson P. B. et al.: J. Med. Chem., 58(1), 147-69, 2015; Mason J. M. et al.: Cancer Cell, 26(2), 163-76, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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