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OD-36 hydrochloride

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SI-7107

OD-36 hydrochloride, >98% (HPLC)

CAS No. : [2387510-88-3]

IUPAC Name : (13Z,15E)-25-Chloro-14,15-dihydro-3,6-dioxa-9-aza-1(3,5)-pyrazolo[1,5-a]pyrimidina-2(1,3)-benzenacyclononaphane hydrochloride

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Chemical Properites
Mol. Formula :
C16H15ClN4O2 • HCl
Mol. Weight :
367.23
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : OD-36 hydrochloride potently inhibits RIPK2 and features a macrocyclic scaffold that enables strong interaction with the ALK2 ATP pocket. Its ALK2‑directed activity (K_D = 37 nM) supports its use in studies of RIPK2 signaling and ALK2‑dependent biological processes.

References : Tigno-Aranjuez J. T. et al.: J. Biol. Chem., 289(43), 29651-64, 2014; Sanchez-Duffhues G. et al.: J. B. M. R. Plus., 3(11), e10230, 2019; Tigno-Aranjuez J. T. et al.: J. Biol. Chem., 289(43), 29651-64, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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