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SI-5173

Oglemilast, >98% (HPLC)

CAS No. : [778576-62-8]

MDL No. : MFCD18633298

Synonyms : GRC 3886

IUPAC Name : N-(3,5-Dichloropyridin-4-yl)-4-(difluoromethoxy)-8-(methylsulfonamido)dibenzo[b,d]furan-1-carboxamide

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Chemical Properites
Mol. Formula :
C20H13Cl2F2N3O5S
Mol. Weight :
516.30
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Oglemilast is a potent and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 0.5 nM for PDE4D3. Oglemilast inhibits pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast has the potential for inflammatory airway diseases.

References : Giembycz M. A. Br. J. Pharmacol., 155(3), 288-90, 2008; Rabe K. F. et al.: Br. J Pharmacol., 163(1), 53-67, 2011; Wunder F. et al. Mol Pharm., 10(10), 3697-705, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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