Olcegepant

SI-7639

Olcegepant, >98% (HPLC)

CAS No. : [204697-65-4]

Synonyms : BIBN-4096; BIBN-4096BS

IUPAC Name : N-(1-((6-Amino-1-oxo-1-(4-(pyridin-4-yl)piperazin-1-yl)hexan-2-yl)amino)-3-(3,5-dibromo-4-hydroxyphenyl)-1-oxopropan-2-yl)-4-(2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Olcegepant selectively blocks the CGRP₁ receptor with picomolar affinity (K_i= 14.4 pM) and sub‑nanomolar functional potency (IC₅₀= 0.03 nM). Its pharmacological profile supports its use in probing CGRP‑dependent signaling and migraine biology.

References : Rudolf K. et al.: J. Med. Chem., 48(19), 5921-31, 2005; Doods H. et al.: Br. J. Pharmacol., 129(3), 420-3, 2000; Edvinsson L. et al.: Eur. J. Pharmacol., 434(1-2), 49-53, 2002; Sixt M. L. et al.: Brain, 132(Pt 11), 3134-41, 2009; Michot B. et al.: Pain, 153(9), 1939-48, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.