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Omadacycline hydrochloride

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SI-5221

Omadacycline hydrochloride, >98% (HPLC)

CAS No. : [1196800-39-1]

MDL No. : MFCD30738014

Synonyms : Amadacycline hydrochloride; PTK 0796 hydrochloride

IUPAC Name : (4R,4aR,5aS,12aR)-4-(Dimethylamino)-7-fluoro-3,10,12,12a-tetrahydroxy-9-((neopentylamino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride

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Chemical Properites
Mol. Formula :
C27H34FN3O7 . HCl
Mol. Weight :
568.04
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Omadacycline hydrochloride is a first-in-class orally active aminomethylcycline antibacterial, which is a member of the tetracycline class of antibiotics. Omadacycline hydrochloride acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline hydrochloride possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline hydrochloride can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections.

References : Duraes F. et, al.: Pharmaceuticals (Basel) 12(2), 63, 2019; Macone A. B. et. al.: Antimicrob Agents Chemother., 58(2), 1127-35, 2014; Zhanel G. G. et. al.: Antibiotic Agent. Drugs 80(3), 285-313, 2020; Markham A. et. al. Drugs 78(18), 1931-1937, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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