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Omidenepag isopropyl

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SI-5271

Omidenepag isopropyl, >98% (HPLC)

CAS No. : [1187451-19-9]

Synonyms : DE-117

IUPAC Name : Isopropyl (6-((N-(4-(1H-pyrazol-1-yl)benzyl)phenylsulfonamido)methyl)pyridin-2-yl)glycinate

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Chemical Properites
Mol. Formula :
C27H29N5O4S
Mol. Weight :
519.62
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration, and Omidenepag is a highly selective EP2 receptor agonist. Omidenepag isopropyl shows only weak affinity for EP1, EP2, and FP receptors. Omidenepag isopropyl is under development for the treatment of glaucoma as an intraocular pressure (IOP)-lowering drug.

References : Kirihara T. et al.: Invest Ophthalmol Vis Sci., 59(1), 145-153, 2018; Fuwa M. et al.: J. Ocul Pharmacol Ther., 34(7), 531-537, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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