Onametostat

SI-6663

Onametostat, >98% (HPLC)

CAS No. : [2086772-26-9]

Synonyms : JNJ-64619178

IUPAC Name : (1S,2R,3S,5R)-3-(2-(2-Amino-3-bromoquinolin-7-yl)ethyl)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclopentane-1,2-diol

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Onametostat potently inhibits PRMT5 with sub‑nanomolar activity (IC₅₀ = 0.14 nM) through a pseudo‑irreversible binding mechanism. It shows robust antiproliferative effects in lung cancer models, supporting its use in studies of PRMT5‑driven tumor biology.

References : Tongfei Wu. et al.: demonstrated in several lung cancer models; Tao H. et al.: Chem. Pharm. Bull., (Tokyo), 67(4), 382-388, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.