Oritinib

SI-7840

Oritinib, >98% (HPLC)

CAS No. : [2035089-28-0]

Synonyms : SH-1028

IUPAC Name : N-(2-((2-(Dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)pyrimidin-2-yl)amino)phenyl)acrylamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Oritinib is an irreversible, third‑generation EGFR inhibitor that effectively suppresses T790M‑mediated resistance in NSCLC. It potently inhibits EGFR^WT and multiple activating and resistance mutations, including L858R, L861Q, L858R/T790M, Δ746‑750, and Δ746‑750/T790M, with IC₅₀ values ranging from 0.1 to 18 nM, underscoring its strong mutant‑selective profile.

References : Han L. et al.: Front Pharmacol., 12, 665253, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.