OSI-027

SI-7742

OSI-027, >98% (HPLC)

CAS No. : [936890-98-1]

Synonyms : ASP-7486

IUPAC Name : (1r,4r)-4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)-1,5-dihydroimidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexane-1-carboxylic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : OSI‑027 inhibits mTOR kinase activity with high potency (IC₅₀ = 4 nM) in an ATP‑competitive manner and blocks both mTORC1 and mTORC2 signaling (IC₅₀ = 22 nM and 65 nM). Its dual‑complex inhibition profile supports its use in mechanistic studies of mTOR‑regulated growth and survival pathways.

References : Carayol N. et al.: Proc. Natl. Acad. Sci. U S A, 107(28), 12469-74, 2010; Falcon B. L. et al.: Cancer Res., 71(5), 1573-83, 2011; Altman J. K. et al.: Clin. Cancer Res., 17(13), 4378-88, 2011; Bhagwat S. V. et al.: Mol. Cancer Ther., 10(8), 1394-406, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.