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Osimertinib impurity I

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Osimertinib impurity I, >98%

CAS No. : [1801616-92-1]

IUPAC Name : 5-Methoxy-N1,N1-dimethyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine

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25MGRequest A Quote
In Stock  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C22H24N6O
Mol. Weight :
388.48
Appearance :
Light brown crystalline solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Osimertinib, which is a third-generation epidermal growth factor receptor (EGFR) inhibitor, used to treat non-small-cell lung carcinomas with a specific mutation.

References : Finlay M. R. et al. J. Med Chem., 57(20), 8249-8267, 2014; Cross D. A. et al.: Cancer Discov., 4(9), 1046-1061, 2014; Eberlein C. A. et al.: Cancer Res., 75(12), 2489-2500, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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