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Osimertinib impurity L

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SL-3721

Osimertinib impurity L, >98%

CAS No. : [2411395-22-5]

Synonyms : Osimertinib N-oxide

IUPAC Name : 2-Acrylamido-N-(2-(dimethylamino)ethyl)-5-methoxy-N-methyl-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)aniline oxide

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Chemical Properites
Mol. Formula :
C28H33N7O3
Mol. Weight :
515.61
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Osimertinib (Osimertinib impurity L), which is a third-generation epidermal growth factor receptor (EGFR) inhibitor, used to treat non-small-cell lung carcinomas with a specific mutation.

References : Finlay M. R. et al. J. Med Chem., 57(20), 8249-8267, 2014; Cross D. A. et al.: Cancer Discov., 4(9), 1046-1061, 2014; Eberlein C. A. et al.: Cancer Res., 75(12), 2489-2500, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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