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Osimertinib impurity M

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Osimertinib impurity M, >98%

CAS No. : [1975982-94-5]

Synonyms : Osimertinib N'-oxide

IUPAC Name : 2-((2-Acrylamido-5-methoxy-4-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)(methyl)amino)-N,N-dimethylethanamine oxide

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Chemical Properites
Mol. Formula :
C28H33N7O3
Mol. Weight :
515.61
Appearance :
Pale green solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Osimertinib (Osimertinib impurity M), which is a third-generation epidermal growth factor receptor (EGFR) inhibitor, used to treat non-small-cell lung carcinomas with a specific mutation.

References : Finlay M. R. et al. J. Med Chem., 57(20), 8249-8267, 2014; Cross D. A. et al.: Cancer Discov., 4(9), 1046-1061, 2014; Eberlein C. A. et al.: Cancer Res., 75(12), 2489-2500, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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