OTS-964

SI-7806

OTS-964, >98% (HPLC)

CAS No. : [1338542-14-5]

IUPAC Name : (R)-9-(4-(1-(Dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : OTS-964 selectively inhibits TOPK with low‑nanomolar potency (IC₅₀ = 28 nM) and also binds CDK11B with high affinity (Kd = 40 nM). Its combined TOPK and CDK11 activity makes it a valuable tool for probing mitotic regulation and transcription‑associated kinase signaling in cancer.

References : Matsuo Y . et al.: Sci. Transl. Med., 6(259), 259ra145, 2014; Lin A. et al.: Sci. Transl. Med., 11(509), 2019; Lu H. et al.: Cell Death Dis., 10(8), 583, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.