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p-Nicorandil

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SL-3578

p-Nicorandil, >98%

CAS No. : [65141-47-1]

Synonyms : 2-[(pyridin-4-ylcarbonyl)amino]ethyl nitrate; Nicorandil EP impurity A

IUPAC Name : 2-(Isonicotinamido)ethyl nitrate

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250MGRequest A Quote
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We accept
Chemical Properites
Mol. Formula :
C8H9N3O4
Mol. Weight :
211.17
Appearance :
Pale yellow solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : p-Nicorandil is an isomeric impurity of Nicorandil (Nicorandil EP impurity A), which is a potassium channel activator, and stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP), used to treat angina.

References : Sato T. et al. J. Am. Coll. Cardiol., 35(2), 514-518, 2000; Akao M.et al.: J. Am. Coll. Cardiol., 40(4), 803-810, 2002; Szczepanik A. M. et al.: J. Pharmacol Exp Ther., 278(2), 913-920, 1996; Teshima Y. et al.: Brain Res., 990(1-2), 45-50, 2003; Sathish V. et al.: Mol Cell Biochem., 243(1-2), 133-138, 2003.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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