P218-hydrochloride

SI-8100

P218-hydrochloride, >98% (HPLC)

CAS No. : [1142407-60-0]

Synonyms : DHFR-IN-5 hydrochloride

IUPAC Name : 3-(2-(3-((2,4-Diamino-6-ethylpyrimidin-5-yl)oxy)propoxy)phenyl)propanoic acid hydrochloride

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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : P218-hydrochloride is an orally active PfDHFR inhibitor with sub‑nanomolar potency (K_i= 0.54 nM) against the quadruple‑mutant enzyme associated with antifolate resistance. It shows clear antimalarial activity in relevant models.

References : Yuthavong Y. et al.: Proc. Natl. Acad. Sci. U. S. A., 109(42), 16823-8, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.