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Padnarsertib

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SI-7221

Padnarsertib, >98% (HPLC)

CAS No. : [1643913-93-2]

Synonyms : KPT-9274

IUPAC Name : (E)-3-(6-Aminopyridin-3-yl)-N-((5-(4-(4,4-difluoropiperidine-1-carbonyl)phenyl)-7-(4-fluorophenyl)benzofuran-2-yl)methyl)acrylamide

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Chemical Properites
Mol. Formula :
C35H29F3N4O3
Mol. Weight :
610.64
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Padnarsertib potently inhibits PAK4 (<100 nM) and NAMPT (120 nM), combining kinase pathway modulation with metabolic disruption. This dual activity makes it a valuable tool for probing cancer cell survival mechanisms.

References : Aboud O. A. et al.: Mol. Cancer Ther., 15(9), 2119-29, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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