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SI-7467

Palacaparib, >98% (HPLC)

CAS No. : [2756333-39-6]

Synonyms : AZD-9574

IUPAC Name : 6-Fluoro-5-(4-((5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl)piperazin-1-yl)-N-methylpicolinamide

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Chemical Properites
Mol. Formula :
C21H22F2N6O2
Mol. Weight :
428.44
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : AZD‑9574 potently and selectively targets PARP1, showing >8000‑fold selectivity over other PARP family members. It efficiently traps PARP1 at single‑strand DNA lesions and penetrates the blood–brain barrier. Its robust anti‑tumor activity supports its use in HRD⁺ breast cancer and advanced solid‑tumor research.

References : Jamal K. et al.: Cancer Res., 82(12), 2609, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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