Palbociclib-2,6-bis aminopyridine impurity

SL-8688

Palbociclib-2,6-bis aminopyridine impurity, >98%

CAS No. : [2458234-37-0]

Synonyms : Palbociclib impurity 21

IUPAC Name : 8-Cyclopentyl-5-methyl-2,6-bis((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

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Applications : This is an impurity of Palbociclib, which is a selective CDK4 and CDK6 inhibitor. Palbociclib is used for the treatment of ER-positive and HER2-negative breast cancer.

References : Fry D. W. et al.: Mol Cancer Ther., 3(11), 1427-1438, 2004; Katsumi Y. et al.: Biochem Biophys Res Commun, 413(1), 62-68, 2011; Goel S. et al.: Nature 548(7668), 471-475, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.