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Palbociclib N-alkylation impurity + C10:C12

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Palbociclib N-alkylation impurity + C10:C12, >98%

IUPAC Name : 6-Acetyl-2-((5-((2-aminoethyl)amino)pyridin-2-yl)amino)-8-cyclopentyl-5-methylpyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride

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5MGRequest A Quote
In Stock  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C22H27N7O2 . HCl
Mol. Weight :
457.96
Appearance :
Yellow solid (hygroscopic)
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Palbociclib, which is a selective CDK4 and CDK6 inhibitor. Palbociclib is used for the treatment of ER-positive and HER2-negative breast cancer.

References : Fry D. W. et al.: Mol Cancer Ther., 3(11), 1427-1438, 2004; Katsumi Y. et al.: Biochem Biophys Res Commun, 413(1), 62-68, 2011; Goel S. et al.: Nature 548(7668), 471-475, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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