Pamapimod

SI-6363

Pamapimod, >98% (HPLC)

CAS No. : [449811-01-2]

Synonyms : RO-4402257; R1503

IUPAC Name : 6-(2,4-Difluorophenoxy)-2-((1,5-dihydroxypentan-3-yl)amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Pamapimod selectively inhibits p38α with low‑nanomolar potency and shows markedly reduced activity toward p38β, with no detectable inhibition of p38γ or p38δ. Its oral bioavailability and defined isoform selectivity make it a valuable tool for investigating p38‑driven inflammatory pathways in autoimmune disease models, including rheumatoid arthritis.

References : Hill. R. J. et al.: The Journal of pharmacology and experimental therapeutics, 327, 610-619, 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.