Pan‑Serotype Dengue inhibitor

SI-8116

Pan‑Serotype Dengue inhibitor, >98% (HPLC)

IUPAC Name : 2-(4-Chloro-2-methoxyphenyl)-2-((3-(2-hydroxyethoxy)-5-methoxyphenyl)amino)-1-(6-methoxy-5-methyl-1H-indol-3-yl)ethan-1-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a high‑potency, pan‑serotype dengue antiviral from the optimized 3‑acyl‑indole series, exhibiting exceptional activity across DENV‑1–4 with EC₅₀ values of 0.00060–0.084 µM. It demonstrates strong chiral stability, robust oral bioavailability in preclinical species, and delivers a dose‑proportional reduction of DENV‑2 viral load in mouse models. These properties position 28a as a leading preclinical small‑molecule candidate for dengue therapeutic development.

References : Kesteleyn B. et al.: J. Med. Chem., 66(13), 8808-8821, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.