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PARP-1/2-IN-1

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SI-6861

PARP-1/2-IN-1, >98% (HPLC)

CAS No. : [1903744-45-5]

IUPAC Name : (R)-1-(3-(3,4-Diethylpiperazine-1-carbonyl)-4-fluorobenzyl)quinazoline-2,4(1H,3H)-dione

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Chemical Properites
Mol. Formula :
C24H27FN4O3
Mol. Weight :
438.5
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This potently inhibits PARP‑1 (IC50 = 0.51 nM) and PARP‑2 (IC50 = 23.11 nM), providing a robust chemical tool for studying PARP‑mediated DNA damage responses and therapeutic strategies targeting DNA repair.

References : Zhou J. et al.: J. Med. Chem., 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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