PARP1/c-Met-IN-1

SI-7595

PARP1/c-Met-IN-1, >98% (HPLC)

CAS No. : [2944101-99-7]

IUPAC Name : 4-(4-Fluoro-3-(4-(4-(2-(6-oxo-3-(pyridin-3-yl)pyridazin-1(6H)-yl)ethoxy)quinolin-7-yl)piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : PARP1/c‑Met‑IN‑1 is a dual PARP1 and c‑Met inhibitor with high potency (IC₅₀ = 3.3 nM for PARP1; 32.2 nM for c‑Met). It induces apoptosis and G2/M cell‑cycle arrest in MDA‑MB‑231 breast cancer cells and demonstrates in vivo antitumor activity in mouse models, supporting its potential as a dual‑pathway therapeutic targeting DNA‑repair and RTK signaling in cancer.

References : Sun Z. et al.: J. Med. Chem., 67(6), 4916-4935, 2024.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.