PD-0166285 dihydrochloride

SI-6771

PD-0166285 dihydrochloride, >98% (HPLC)

CAS No. : [212391-63-4]

IUPAC Name : 6-(2,6-Dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride

Price And Availability
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25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : PD-0166285 dihydrochloride selectively targets WEE1 with nanomolar potency (IC₅₀ = 24 nM), displays weaker inhibition of Myt1 (IC₅₀ = 72 nM), and shows low‑micromolar activity against Chk1 (IC₅₀ = 3.433 µM). As a P‑gp substrate, it is a valuable tool for dissecting WEE1‑dependent checkpoint control and kinase cross‑reactivity.

References : Wang Y. et al.: Cancer Res., 61(22), 8211-7, 2001; Mark. C. de Gooijer et al.: Invest. New Drugs., 36(3), 380-387, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.