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PD-0183812

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SI-7790

PD-0183812, >98% (HPLC)

CAS No. : [241180-26-9]

IUPAC Name : 8-(Bicyclo[2.2.1]heptan-2-yl)-2-((4-(4-(3-hydroxypropyl)piperidin-1-yl)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

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Chemical Properites
Mol. Formula :
C28H35N5O2
Mol. Weight :
473.62
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : PD‑0183812 is a potent cyclin‑dependent kinase (CDK) inhibitor, blocking multiple CDK isoforms involved in cell‑cycle progression and transcriptional regulation. It is widely used as a tool compound to study CDK‑driven proliferation, checkpoint control, and apoptosis in cancer biology.

References : Park H. et al.: ChemBioChem., 5(12), 1662-72, 2004; Fry D. W. et al.: J. Biol Chem., 276(20), 16617-23, 2001.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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