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PD-123319

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SI-5827

PD-123319, >98% (HPLC)

CAS No. : [130663-39-7]

MDL No. : MFCD00896427

IUPAC Name : (S)-1-(4-(Dimethylamino)-3-methylbenzyl)-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid

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Chemical Properites
Mol. Formula :
C31H32N4O3
Mol. Weight :
508.62
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : PD-123319 is a potent, selective AT2 angiotensin II receptor antagonist with IC50 of 34 nM.

References : Blankley C. J. et al.: J. Med Chem., 34(11), 3248-60, 1991; Boulay G. et al.: Mol. Pharmacol., 41(4), 809-15, 1992; Estrup T. M. et al.: J. Renin Angiotensin Aldosterone Syst., 2(3), 188-92, 2001; Brillante D. G. et al.: J. Renin Angiotensin Aldosterone Syst., 6(2), 102-6, 2005.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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