Pemetrexed dimer (S) diasteromer

SL-3739

Pemetrexed dimer (S) diasteromer, >98%

CAS No. : [1802552-16-4]

Synonyms : Pemetrexed EP impurity C

IUPAC Name : (2S,2'S)-2,2'-((4,4'-(((S)-2,2'-diamino-4,4',6-trioxo-4,4',5,6,7,7'-hexahydro-1H,3'H-[5,6'-bipyrrolo[2,3-d]pyrimidine]-5,5'-diyl)bis(ethane-2,1-diyl))bis(benzoyl))bis(azanediyl))dipentanedioic acid

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Applications : This is an impurity of Pemetrexed (Pemetrexed EP impurity C), which is a novel antifolate and antimetabolite for dihydrofolate reductase-thymidylate synthase (DHFR-TS). It is used to treat for pleural mesothelioma (cancer of the outer covering of the lungs) non small cell lung cancer (NSCLC).

References : Shih C. et al.: Cancer Res., 57(6), 1116-1123, 1997; Iwahori K. et al.: Int J. Cancer., 132(2), 459-471, 2013; Teicher B. A. et al.: Clin. Cancer Res., 6(3), 1016-1023,2000.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.