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Perospirone-d8

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Perospirone-d8, >98%

Related CAS No. : [129273-38-7] of the unlabelled compound

Synonyms : SM-9018-d8

IUPAC Name : (3aR,7aS)-2-(4-(4-(Benzo[d]isothiazol-3-yl)piperazin-1-yl)butyl-1,1,2,2,3,3,4,4-d8)hexahydro-1H-isoindole-1,3(2H)-dione hydrochloride

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Chemical Properites
Mol. Formula :
C23H22D8N4O2S • HCl
Mol. Weight :
471.09
Appearance :
Pale brown solid (hygroscopic)
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a deuterium labelled version of Perospirone, which is an orally active compound that acts as an antagonist at the 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and as a partial agonist at the 5-HT1A receptor (Ki=2.9 nM). It is classified as an atypical antipsychotic and is used in research related to schizophrenia.

References : Kato T. et al.: pn J. Pharmacol., 54(4), 478-81, 1990; Hagiwara H. et al.: Eur. Neuropsychopharmacol., 18(6), 448-54, 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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