Pevonedistat

SI-6248

Pevonedistat, >98% (HPLC)

CAS No. : [905579-51-3]

Synonyms : MLN-4924

IUPAC Name : ((1S,2S,4R)-4-(4-(((S)-2,3-Dihydro-1H-inden-1-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate

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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : Pevonedistat inhibits the NEDD8‑activating enzyme with nanomolar potency (IC₅₀ = 4.7 nM), resulting in impaired cullin‑RING ligase function and deregulated S‑phase DNA synthesis. This mechanism drives apoptosis in tumor cells and yields robust tumor‑growth suppression in mouse xenograft studies.

References : Soucy T. A. et al.: Nature, 458(7239), 732-6, 2009; Wolenski S. F. et al.: Cell Death Discovery 1, 15034 , 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.