Pexidartinib

SI-5688

Pexidartinib, >98% (HPLC)

CAS No. : [1029044-16-3]

MDL No. : MFCD28900745

Synonyms : PLX-3397

IUPAC Name : 5-((5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
100MG	155.00		Back Order	Estimated to ship on 04 October 2026
250MG	255.00		Back Order	Estimated to ship on 04 October 2026
1G	525.00		Back Order	Estimated to ship on 04 October 2026
5G	1795.00		Back Order	Estimated to ship on 04 October 2026

Applications : Pexidartinib is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF-1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib exhibits 10- to 100-fold selectivity for c-Kit and CSF-1R over other related kinases. Pexidartinib induces cell apoptosis and has anticancer activity.

References : DeNardo D. G. et al.: Cancer Discov., 1(1), 54-67, 2011; Kuse Y. et al.: Mol Vis., 24, 536-545, 2018; Lee J. H. et al.: Invest New Drugs 38(1), 99-110, 2020; Merry T. L. et al.: Int. J. Obes (Lond) 44(1), 245-253, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.