Pexidartinib hydrochloride

SI-5689

Pexidartinib hydrochloride, >98% (HPLC)

CAS No. : [2040295-03-0]

Synonyms : PLX-3397 hydrochloride

IUPAC Name : 5-((5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine hydrochloride

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
250MG	225.00		Back Order	Estimated to ship on 04 October 2026
1G	435.00		Back Order	Estimated to ship on 04 October 2026
5G	1695.00		Back Order	Estimated to ship on 04 October 2026

Applications : Pexidartinib hydrochloride is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF-1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF-1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anticancer activity.

References : DeNardo D. G. et al.: Cancer Discov., 1(1), 54-67, 2011; Kuse Y. et al.: Mol Vis., 24, 536-545, 2018; Lee J. H. et al.: Invest New Drugs 38(1), 99-110, 2020; Merry T. L. et al.: Int. J. Obes (Lond) 44(1), 245-253, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.