Pexmetinib

SI-6368

Pexmetinib, >98% (HPLC)

CAS No. : [945614-12-0]

Synonyms : ARRY-614

IUPAC Name : 1-(3-(Tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)benzyl)urea

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Pexmetinib selectively targets Tie‑2 and p38α/β with low‑nanomolar potency (IC₅₀ = 1/35/26 nM), providing a dual‑pathway inhibitor relevant to the investigation of AML biology, particularly in models involving dysregulated angiogenic and inflammatory signaling.

References : Bachegowda L. et al.: Cancer Res., 76(16), 4841-4849, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.