Pexmetinib hydrochloride

SI-6369

Pexmetinib hydrochloride, >98% (HPLC)

CAS No. : [1416216-01-7]

IUPAC Name : 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(5-fluoro-2-((1-(2-hydroxyethyl)-1H-indazol-5-yl)oxy)benzyl)urea;hydrogen chloride

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Pexmetinib hydrochloride is a potent dual Tie‑2/p38 MAPK inhibitor, showing low‑nanomolar activity against Tie‑2 (IC₅₀ ≈ 1 nM) and p38α/β (35/26 nM). It is widely used in acute myeloid leukemia (AML) research to probe angiogenic and inflammatory signaling driven by Tie‑2/p38 pathways.

References : Bachegowda L. et al.: Cancer Res., 76(16), 4841-4849, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.