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PF-03814735

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SI-4895

PF-03814735, >98% (HPLC)

CAS No. : [942487-16-3]

IUPAC Name : N-(2-((1S,4R)-6-((4-(Cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl)-2-oxoethyl)acetamide

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Chemical Properites
Mol. Formula :
C23H25F3N6O2
Mol. Weight :
474.48
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : PF-03814735 is a potent, orally available and reversible aurora A and aurora B inhibitor with IC50s of 0.8 and 0.5 nM

References : Jani J. P. et al.: Mol Cancer Ther., 9(4), 883-894, 2010; Hook K. E. et al.: Mol Cancer Ther., 11(3), 710-719, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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