PF-04995274

SI-6741

PF-04995274, >98% (HPLC)

CAS No. : [1331782-27-4]

IUPAC Name : (R)-4-((4-(((4-((Tetrahydrofuran-3-yl)oxy)benzo[d]isoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : PF‑04995274 is an orally active, brain‑penetrant partial agonist of the 5‑HT₄ receptor, exhibiting sub‑nanomolar potency across human and rat 5‑HT₄ isoforms. With EC₅₀ values of 0.26–0.47 nM (human) and 0.59–0.65 nM (rat), it serves as a valuable tool for investigating 5‑HT₄‑mediated enhancement of cognition and its therapeutic relevance to Alzheimer’s disease.

References : Chen. B. K. et al.: Neuropsychopharmacology., 2019; Grimwood S. et al.: Alzheimer’s Dement: J Alzheimer’s Assoc. 7, S653, 2011; Timothy Nicholas1. et al., Advances in Alzheimer's Disease. Vol.2 No.3., 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.