PF-05186462

SI-7647

PF-05186462, >98% (HPLC)

CAS No. : [1235406-03-7]

IUPAC Name : 5-Chloro-2-fluoro-4-(2-(pyridazin-4-yl)-4-(trifluoromethyl)phenoxy)-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : PF‑05186462 selectively blocks the human NaV1.7 channel with nanomolar potency (IC₅₀= 21 nM) and shows minimal activity at other NaV family members. Its high selectivity and functional profile make it valuable for studying NaV1.7‑mediated neuronal excitability and pain pathways.

References : Jones H. M. et. al.: Clin. Pharmacokinet., 55(7), 875-887, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.