PF-05221304

SI-6085

PF-05221304, >98% (HPLC)

CAS No. : [1370448-25-1]

IUPAC Name : 4-(4-(1-Isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Clesacostat selectively inhibits human ACC1 and ACC2 with low‑nanomolar potency (IC₅₀ = 13/9 nM). Its liver‑targeted design and strong dual‑isoform inhibition support its use in studies of hepatic fatty‑acid synthesis and metabolic disorders.

References : Huard K. et al.: J .Med. Chem., 63(19), 10879-10896, 2020; Calle R. A. et al.: Nat. Med., 27(10), 1836-1848, 2021; Ross T. T. et al.: Cell Mol. Gastroenterol. Hepatol., 10(4), 829-851, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.