PF-06827443

SI-1616

PF-06827443, 98% (HPLC)

CAS No. : [2115022-67-6]

Synonyms : PF06827443

IUPAC Name : 2-((3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl)-5-methyl-6-(4-(oxazol-4-yl)benzyl)isoindolin-1-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : PF-06827443 is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with EC₅₀ of 47 nM, shows no activity against M2-M5 at 10 uM.

References : Davoren E. J. et al.: J. Med. Chem., 60(15), 6649-6663, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.