PF-06835919

SI-6095

PF-06835919, >98% (HPLC)

CAS No. : [2102501-84-6]

Synonyms : Ketohexokinase inhibitor 1

IUPAC Name : 2-((1R,5S,6R)-3-(2-((S)-2-Methylazetidin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)acetic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : PF‑06835919 inhibits KHK with nanomolar potency (IC₅₀ = 8.4 nM for KHK‑C; 66 nM for KHK‑A), effectively targeting the first committed step in fructose metabolism. Its activity profile supports its use in models of fructose‑driven metabolic disorders.

References : Kentaro F. et al.: J. Med. Chem., 63(22), 13546-13560, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.