PF-06862309

SI-6277

PF-06862309, >98% (HPLC)

CAS No. : [2067281-52-9]

IUPAC Name : 2,2-Difluoroethyl (S)-3-((2'-amino-5-fluoro-2-morpholino-[4,5'-bipyrimidin]-6-yl)amino)-3-((phosphonooxy)methyl)pyrrolidine-1-carboxylate

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : PF‑06862309 is a prodrug that is hydrolyzed by alkaline phosphatase to yield PF‑06843195, a highly selective PI3Kα inhibitor. Its ability to deliver PI3Kα‑targeted activity makes it valuable for mechanistic and therapeutic studies in ER⁺/HER2^-/PIK3CA‑mutant breast cancers.

References : Cheng H. et al.: J. Med. Chem., 64(1), 644-661, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.