PF-07258669

SI-7262

PF-07258669, >98% (HPLC)

CAS No. : [2755890-53-8]

IUPAC Name : (S)-2-(5-Fluoro-2-methoxypyridin-4-yl)-1-((R)-7'-methyl-6'-(pyrimidin-2-yl)-3',4'-dihydro-1'H-spiro[pyrrolidine-3,2'-[1,8]naphthyridin]-1-yl)propan-1-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : PF‑07258669 selectively antagonizes MC4R with nanomolar potency (IC₅₀ = 13 nM; K_i = 0.46 nM) and serves as a valuable tool compound for investigating MC4R‑mediated mechanisms in metabolic and appetite‑related disorders, including cachexia and anorexia.

References : Garnsey M. R. et al.: J. Med.Chem., 66(5), 3195-3211, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.